解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Apnea of prematurity (AOP) occurs frequently in preterm infants and a variable proportion of AOP can be induced by gastroesophageal reflux (GER). Conservative treatment, including dietary modifications, should be the first-line approach for both GER and GER-related apneas in this population. OBJECTIVES:To e...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000342703
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:We hypothesized that color Doppler-measured cerebral blood flow velocity (CD-CBFV) as measured in the three feeding arteries of the brain can be used as an estimator of global cerebral blood flow. PATIENTS AND METHODS:CD-CBFV was determined as soon as possible after determination of phase-contrast magnetic ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000342336
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Higher patient-to-nurse ratios and nursing workload are associated with increased mortality in the adult intensive care unit (ICU). Most neonatal ICUs (NICUs) in the United Kingdom do not meet national staffing recommendations. The impact of staffing on outcomes in the NICU is unknown. OBJECTIVE:To determin...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000353458
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Ventilatory pressures should target the range between the upper and lower inflection point of the pressure volume curve in order to avoid atelecto- and volutrauma. During high-frequency oscillatory ventilation (HFOV), this range is difficult to determine. Quadrant impedance measurement (QIM) has recently bee...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000345612
更新日期:2013-01-01 00:00:00
abstract:UNLABELLED:Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo-...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000351346
更新日期:2013-01-01 00:00:00
abstract::We report the successful and safe use of levosimendan, a new calcium-sensitizing agent with positive inotropic and vasodilatory action, in 2 critically ill term newborns with acute heart failure and pulmonary hypertension in the absence of any underlying heart malformation and/or previous cardiosurgical procedures. Du...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000329848
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:Non-invasive cardiac output monitoring is a potentially useful clinical tool in the neonatal setting. Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates. METHODS:In this prospective observational study, ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000337295
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Intermittent hypoxic episodes are common among preterm infants, although longer term consequences on growth pattern and cardiovascular regulation are unclear. Furthermore, the effects of intermittent hypoxia (IH) may depend on the pattern of hypoxia-reoxygenation. OBJECTIVES:We tested the hypothesis that a ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000338096
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:For quick detection or exclusion of neonatal early-onset bacterial infection (EOBI) or late-onset bacterial infection (LOBI), interleukin (IL)-6 is used. Its clinical use is sometimes limited due to prolonged recall times. Therefore, an IL-6 bedside test was established. OBJECTIVE:To compare the diagnostic ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000336632
更新日期:2012-01-01 00:00:00
abstract::Treatment of sick neonates originated in maternity and foundling hospitals in the 19th century. Nosocomial infections and difficult logistics of wet-nursing prevented admission of neonates in most children's hospitals well into the 20th century. In this article, 31 hospitals are described, all located in large cities,...
journal_title:Neonatology
pub_type: 历史文章,杂志文章
doi:10.1159/000336285
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Pharmacological closure of patent ductus arteriosus (PDA) is commonly achieved by intravenous (IV) administration of ibuprofen or indomethacin. Occasionally, oral ibuprofen is used for PDA treatment although its efficacy and safety are unclear. OBJECTIVES:To systematically review randomized and quasi-random...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000335332
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Early host-microbe interaction provides important maturational stimuli for the developing immune system. The role of prenatal microbial contact remains elusive. OBJECTIVES:Our aim was to investigate whether microbes in placenta or amniotic fluid affect fetal innate immune gene expression during late pregnan...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000339182
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Gene expression profiling of the salivary supernatant is emerging as a new and important source of real-time, systemic, biological information. However, existing technologies prevent RNA extraction of small quantities found in neonatal salivary supernatant. OBJECTIVE:The aim of this study was to develop tec...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000328026
更新日期:2012-01-01 00:00:00
abstract::This paper describes a neonate with type II Gaucher disease. The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure. Electron microscopy of the skin revealed lamellar body contents in the stratum corneum interstices, appearances consider...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000324116
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Sustained lung inflation (SLI) applied at birth has been demonstrated to lead to clearance of lung fluid and achievement of a precocious functional residual capacity in animal studies. OBJECTIVES:To verify if the application of SLI in preterm infants at birth may reduce the need for mechanical ventilation a...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000298312
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Closed endotracheal suction interferes with mechanical ventilation received by infants, but the change to ventilation may be different when ventilator modes that target expired tidal volume (VT(e)) are used. OBJECTIVE:To measure airway pressure and tidal volume distal to the endotracheal tube (ETT) during a...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000316854
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Premature birth and respiratory distress syndrome (RDS) are risk factors for disturbed lung development and bronchopulmonary dysplasia (BPD). The molecular mechanisms related to prematurity and BPD remain largely unknown. Epithelial expression of the transcription factor GATA-6 has been implicated in normal ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000317827
更新日期:2011-01-01 00:00:00
abstract::Ductus arteriosus and foramen ovale were described by Galen without understanding their functions. His beliefs in soul localization and spiritization within the left ventricle established religious pneumatology which became a theological need in the Middle Ages. Pulmonary transit was recognized by Servetus and Colombo...
journal_title:Neonatology
pub_type: 历史文章,杂志文章
doi:10.1159/000308367
更新日期:2011-01-01 00:00:00
abstract::We describe three positive influenza AH1N1 cases in a neonatal unit during the influenza pandemic in Spain. One term baby presented with an upper respiratory tract infection, another preterm infant with an apnea episode following nosocomial infection, and thirdly, a term infant of a mother with influenza AH1N1 had sev...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000324232
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The causes of bronchopulmonary dysplasia (BPD) are multifactorial. Overdistension of the lung (volutrauma) is considered an important contribution. As an alternative to traditional pressure-limited ventilation (PLV), modern neonatal ventilators offer modes which can target a set tidal volume. OBJECTIVES:To ...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000326080
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The clinical significance of early transient hypoglycemia (ETH), a frequent event in preterm newborns, is a highly controversial issue. In experimental models, hypoglycemia has been reported to cause oxidative stress. Among the reactive species, early generated peroxynitrite is responsible for protein nitrat...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000326936
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:International neonatal resuscitation guidelines recommend assessing chest excursion when the heart rate is not improving. However, the accuracy in assessing 'adequate' chest excursion lacks objectivity. AIM:It was the aim of this study to test the accuracy in the assessment of 'adequate' chest excursion by ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000322009
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Faecal calprotectin has been proposed as a sensitive marker for gastrointestinal inflammation in children and adults. High levels have been reported in healthy newborns and during the first months of life; the effect of the kind of feeding on the calprotectin concentration in stools is controversial. OBJECT...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000255161
更新日期:2010-06-01 00:00:00
abstract::Despite recent advances in the perinatal management of neonatal respiratory distress syndrome (RDS), controversies still exist. We report the updated recommendations of a European panel of expert neonatologists who had developed consensus guidelines after critical examination of the most up-to-date evidence in 2007. T...
journal_title:Neonatology
pub_type: 杂志文章,实务指引
doi:10.1159/000297773
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000261018
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Corticosteroids have been used widely after birth in preterm infants with respiratory failure; hydrocortisone may be preferable to other corticosteroids for this purpose. OBJECTIVES:To determine if postnatal hydrocortisone is useful to prevent or treat bronchopulmonary dysplasia (BPD) in preterm infants. M...
journal_title:Neonatology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000279992
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Nosocomial infections endanger preterm infants. OBJECTIVE:The aim of the present controlled randomized trial was to investigate whether Bifidobacterium lactis reduces the incidence of nosocomial infections in infants with very low birth weight (VLBW; <1,500 g) <30 weeks of gestation. PATIENTS AND METHODS:I...
journal_title:Neonatology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000280291
更新日期:2010-01-01 00:00:00
abstract:AIM:To determine the prevalence of renal anomalies in patients with an isolated single umbilical artery (SUA). METHODS:We performed a retrospective study of all renal ultrasound examinations assessed at our centre between January 1998 and December 2008 in neonates with SUA with or without associated anomalies. RESULT...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000253151
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:No survey has been published in recent years which primarily focuses on the prescription of inhaled corticosteroids in neonatal practice. Thus, the utilization rate of inhaled corticosteroids is unknown. OBJECTIVES:To elucidate the current utilization rate of inhaled corticosteroids in the prevention and th...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000316978
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Various studies have shown an association between low birth weight and the prevalence of elevated blood pressure later in life. However, a relationship between birth weight and blood pressure in the neonatal period has not been investigated yet. OBJECTIVE:To study the relationship between birth weight and b...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000203338
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Carriers of Staphylococcus aureus strains can be the source of epidemic infection for patients. OBJECTIVES:A molecular epidemiological analysis of an impetigo bullosa outbreak in a neonatal ward was performed in order to determine a potential source of the infection and possible routes of subsequent spreadi...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000204961
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Genetic processes underlying fetal lung development and maturation are incompletely understood. Better knowledge of these processes would provide insights into the causes of lung malformations and prevention of respiratory distress syndrome and the potential adverse effects of glucocorticoids. Hox genes are ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000201739
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Despite increasing survival in the smallest preterm infants, the incidence of chronic lung disease has not decreased. Research into ventilatory strategies has concentrated on minimising barotrauma, volutrauma and atelectotrauma, but little attention has been paid to the role of bias gas flow rates and the po...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000220765
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Oxidative stress in the newborn period may cause cell injury and inflammation if the antioxidant capacity is insufficient. To monitor antioxidant and inflammatory activity we examined by in vivo imaging various strains of luciferase reporter mice whose light-emitting properties were regulated by response e...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000107777
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:While hypoxic events with bradycardias are a frequent occurrence during the first weeks of life in preterm infants, the impact of preterm birth on maturation of the cardiovascular response to hypoxia in early postnatal life is unknown. OBJECTIVES:In the present study, we tested the hypothesis that preterm b...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000110868
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The postnatal heart responds to biomechanical stress with hypertrophy. The fetal heart may also undergo hyperplasia, but the percentage of mitotically active cardiomyocytes decreases throughout gestation. The signaling pathways controlling growth and proliferation in the fetal heart are poorly understood. O...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000107729
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Extreme hyperbilirubinemia is treated with double volume exchange transfusion, which may take hours to commence. A neuroprotective agent that could be administered immediately might be clinically useful. Minocycline, an anti-inflammatory and anti-apoptotic semisynthetic tetracycline, prevents hyperbilirubine...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000103740
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Inflammation due to perinatal infection (PI) and perinatal asphyxia (PA) may cause damage to various tissues and very often to the immature brain of the fetus and the newborn. Previously, we have shown that the neonatal immune system has the ability to produce increased chemokine protein levels in the serum ...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000097127
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:High-dose recombinant erythropoietin (rEpo) is neuroprotective in neonatal animal models of brain injury, but the long-term consequences of neonatal exposure have not been studied. OBJECTIVES:We hypothesized that multiple injections of high-dose rEpo during the neonatal period would be safe, and would impro...
journal_title:Neonatology
pub_type: 杂志文章
doi:10.1159/000096969
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Serum ferritin measurements are used in clinical populations to estimate total body iron stores and the risk of subsequent iron deficiency or overload. The lack of normative newborn serum ferritin concentration data between 23 and 41 weeks has led to difficulty in establishing the incidence and degree of abn...
journal_title:Neonatology
pub_type: 杂志文章,评审
doi:10.1159/000100805
更新日期:2007-01-01 00:00:00